For reproduction of material from PPS: Reproduced from Ref.XX with permission from the PCCP Owner Societies. For reproduction of material from PCCP: Reproduced from Ref.XX with permission from the Centre National de la Recherche Scientifique (CNRS) and The Royal Society of Chemistry. For reproduction of material from NJC: Reproduced from Ref.This protocol also worked well with coumarin-3-carboxylic acids to unveil a rare instance of a catalyst-free tandem alkylation/decarboxylation reaction with conservation of the double bond.
This protocol employs tert-butyl hydroperoxide as the sole reagent of the reaction to combine coumarins and ethers in reasonable yields under metal- and solvent-free reaction conditions. A regioselective direct alkylation of coumarins at C-3 via cross-dehydrogenative coupling of unactivated Csp 2–Csp 3 bonds is developed.
